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Post-therapy PSA levels have become widely accepted as a surrogate end point in the evaluation of treatment responses in hormone-refractory prostate cancer (Smith et al, 1998).
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In most of the clinical studies with citicoline in VD, memory has been the principal end point in the efficacy evaluation.
The development of biomarker strategies could be part of a movement toward more ecologic end points in the safety evaluation of chemicals, which would effect a reduction in animal tests that cause suffering.
A decrease in haemoglobin of ≥2 g/dL has previously been considered as a clinically meaningful end point 18 in the evaluation of GI toxicity in NSAID users.
Skeletal-related events (SREs) are an objective, clinically relevant end point for the evaluation of disease-related complications in patients with bone metastases [ 1].
The primary end point was the evaluation of safety and tolerability.
Biomarkers have been used as intermediate end points to optimize the evaluation of these agents in trials (Groopman et al. 2005).
The secondary end-point was the evaluation of the new schedule toxicity.
The primary end-point is the evaluation of the cost-effectiveness of treatment strategies by incremental net-benefit analysis [ 43].
Although the observed efficacy of most end points was largely comparable with previous evaluations in this population (Munoz et al, 2009), there were exceptions, particularly for the HPV 16- and 18-related end points in the ITT population (Table 2).
After final evaluation by the endpoint committee with review of patient charts a total of 102 strokes in 92 patients were identified and these 92 patients were analysed as end points in the present report.
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