Exact(3)
The end point for determining infarct volume was 24 h following onset of ischemia, a standard timepoint for neuroprotective studies.
Its use as an end point for determining the adequacy of hemodynamics (blood pressure, cardiac output/cardiac index), measurement of right to left shunt, and prediction of potential hemodynamic instability makes this parameter invaluable for the knowledgeable clinician.
These data also demonstrate that BPA induces estrogenic changes in the uterus of the CD-1 mouse, and highlight the need to reevaluate the validity of the mouse uterotrophic assay as an end point for determining the estrogenicity of suspected environmental estrogens.
Similar(57)
As such, reports describing the use of T2-weighted MRI to depict the AAR have been met with enthusiasm, and there has been early integration of this technique into randomized clinical trials to provide end points for determining therapeutic efficacy.
In order to establish which methods, other than mutation screening, might provide reliable end points for determining ATM heterozygosity, we have compared the cellular phenotype before and after exposure to IR of AT heterozygote cell lines with that seen in cell lines carrying a wild type or homozygous mutated ATM gene.
Cells were tracked and migration speed (in µm/min) and persistence (displacement/track length, where displacement is the distance from the start to end point for each cell) were determined using ImageJ analysis software (http://rsb.info.nih.gov/ij) and ibidi chemotaxis and migration tool (www.ibidi.com).
For HPAIV challenge viruses, the chicken lethal dose of 50 (CLD50) was determined by infecting 3 chickens (5-wk-old) per group, and the 50% end point for the lethal dose was determined by the Reed and Muench method [36].
Since complete failure of the beam in the three point bending test is approached asymptotically (Petersson 1981), an end point for the test could not be determined.
The connectivity of these components was used to determine the end point for the filtering process.
Receiver operating curve was used to determine the optimal cutoff point based on progression end point for p-PP2A expression as previously described (Generali et al, 2009).
Therefore, although acute inflammatory end points may not be the most useful for determining chronic disease such as fibrosis or carcinogenesis, acute inflammation is still the most sensitive end point for toxicity ranking.
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