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Despite the promise of proangiogenic gene therapy most clinical trials have failed to show benefit for the primary end point analysis.
In particular, we discuss the poor translation of drug efficacy from preclinical animal models, inappropriate end point analysis, limited standards in phase I clinical trials, insufficient use of biomarker analysis and also patient stratification, all of which contributed to the failure to achieve approval of enzastaurin as an anticancer therapeutic.
Safety end point analysis is required to address drug risk.
Therefore, primary end point analysis indicated pelubiprofen was non-inferior to celecoxib.
4 We estimated that 200 patients would be enrolled in the primary end point analysis.
JLM was the study pathologist and significantly contributed to the end point analysis.
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Furthermore, continuous video provides insight into kinetics beyond what is possible with end-point analysis alone.
As such, quantitating infectious viral titers using the TCID50 assay was an appropriate end-point analysis for this work.
In the principal end-point analysis of annualized number of new arrests, 26% of standard-care clients were rearrested versus 8% on XR-NTX (RRR = 69%; p <.05).
There are two general approaches to characterizing the mass-flux-reduction/mass-removal relationship, end-point analysis and time-continuous analysis.
End-point analysis, based on comparing masses and mass fluxes measured before and after a source-zone remediation effort, was conducted for 21 remediation projects.
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