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This is particularly true in the joint where the synovial membrane, synovial fluid, vasculature, nervous supply, cartilage and underlying subchondral bone all contribute to the end pathology, making elucidation of specific molecular events within one tissue type difficult to isolate and more difficult to interpret.
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He admits to playing his own part in perpetuating the dead-end pathology of violence begetting violence.
Since toxoplasmosis is a complex disease, multiple genes and modifiers will contribute to end stage pathology.
Hence, we do not expect that end stage pathology seen in congenital toxoplasmosis will be the same as that observed in the case of a very specific genetic disorder like Stickler's disease.
Patients with systemic causes, (e.g., the vasculitides) may experience weight loss, fevers, or symptoms related to various, disease-specific end organ pathologies.
The current study compared polysomnographic findings of two groups of patients with clinically stable but severe end-stage pathology of the liver and heart.
Furthermore, the pathophysiological pathways that link the normal pancreas to the end-stage pathology of CP have not been clearly defined.
End-stage pathology revealed approximately 60%% motor neuron loss from the lumbar spinal cord.
Therefore, some investigators suggest that ALK− ALCL may represent the end-stage pathology of various T-cell lymphomas [38].
First, it is possible that the changes in Case 2 represent "end-stage" pathology resulting from cumulative and repetitive metabolic insults.
However, the evaluation of structural matrix components and proteases affecting those components is still of interest because the end-stage pathology characterising canine OA mimics that described for human OA [ 40].
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