As already apparent from the analysis of "druggable" genes both within specific gene classes (Figure 4A) and the whole genome (Figure 4B) and based on the fact that the large majority of drug target genes (86%) was protected by patents, drug targets mostly clustered at the high end of the characterization scale.
Even though both families of ion-channel genes lacked genes remaining at the very low end of the characterization scale, there still was prospect of novel therapeutic applications owing to hitherto untargeted subunits of target protein complexes and family members regulating protein structure.
Murray's continuing mission: put a ceremonious end to the characterization of the current elite, in so many words, as the Big Three and maybe.
In the end, if the characterization of Zeno's treatise by Plato's Socrates in the passage above is not quite accurate, there remains no more plausible view from antiquity regarding the general thrust of his arguments, to the extent that there may have been a single one.
Analysis of RNA 5′ ends allowed the characterization of crRNA maturation sites at the nucleotide level, showing that crRNAs resulted from processing at two sites, as previously observed in S. pyogenes [ 58] (Additional file 15).
This interpretation is based on an end-of-life characterization, aimed to investigate catalyst, electrode and membrane degradation, by determining hydrogen crossover rates, high frequency resistances, electrochemically active surface areas and catalyst particle sizes.
To this end, efforts toward the characterization of the majority of the strains-specific genes with unknown function (hypothetical proteins) will be critical.
The choice of central subject, the decision as to when to begin and when to end the story, the characterization of the principal actors, the drawing out of moral import, and the identification of turning points are all activities that both historians and novelists perform.
To this end, we pursued the characterization of IL-10-producing B cells in a model of infection by the intracellular bacterial pathogen Salmonella typhimurium.
Unexpectedly, analysis of the sequence allowed the characterization of the 5' end of the ubi gene positioned 6 nts upstream the putative AUG.
Morphological characterization at the end of the first summer indicated significant differences between provenances for plant height (mean values from 99 to 133 cm), petiole length (1.8 2.5 cm), width of the leaf blade (3.6 5.1 cm), ratio leaf length/width (1.9 2.2) and leaf area (16 30 cm2).
