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Additional stocks of Tamiflu are due to reach their end of shelf life and be replaced during 2013-14 at a cost of £49 million, the NAO said.
The end of shelf life of fresh-cut iceberg lettuce packed in modified atmosphere (MA) is determined by its visual quality and by its microbial load.
Extrapolation of 24 months' formulation robustness data to end of shelf life showed that the MAb formulation was robust within the claimed formulation composition ranges.
Stability studies are important tools to reliably ensure that efficacy and safety of medicinal products will remain unchanged from release of drug product until the end of shelf life.
The microbiological composition of the active drink at the end of shelf life met targets of 1 × 10 cfu/g of L. casei DN-114 001.
The end of flavour life, due to changes in sugar, acids and aroma volatiles and the development of off flavours (mainly caused by fermentative metabolism), often precedes the end of shelf life as determined by visual and textural features (Kader 2003, 2008).
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And yet here it was, in 2011, on an end-of-shelf display.
They ran a free-breakfasts-for-children programme, using donated end-of-shelf-life food.
A multivariate formulation robustness study was performed for a selected formulation of a monoclonal antibody to demonstrate acceptable quality at the target composition as well as at the edges of the allowable composition ranges and fulfillment of the end-of-shelf-life stability requirements of 36 months at the intended storage temperature (2°C-8°C).
Based on this case study, we propose that a formulation can be claimed as "robust" if all drug substance and drug product critical quality attributes remain within their respective end-of-shelf-life critical quality attribute acceptance criteria throughout the entire claimed formulation composition range.
These data also suggest that changing end-of-shelf-life specifications such that vaccine at expiry contains one-half the recommended antigen dose, is unlikely to impact clinical potency, but would allow for the extended use of available vaccine stocks.
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