Complete folding and dimerization of larger ICDH (46 kDa) requires the presence of C-terminal sequences and will be retarded until this information is available at the end of synthesis, rendering the protein more sensitive to proteolysis.
Moreover, deletion of the non-conserved C-terminal end of CAM2, rendering a protein with 186 amino acids (CAM2_186), abolished the incipient ProFAR isomerase activity found in CAM2 (Additional file 1: Figure S2).
A comparison of tumors, isolated from drug-free control and ATL-treated MCL-bearing mice, at the end of treatment rendered a dramatic reduction of tumor weight and volume in mice treated with edelfosine or perifosine.
It is enough, in the very end, to render them unable to drink so they die, semi-conscious, of thirst.
Studios are offering high-velocity intensity or, at the other end of the spectrum, rendering students unconscious on their mats, wrapped in comfort blankets as they reach for a state of "sleepless sleep".
A death could spell the end of the company, rendering the watches worthless.
Having built a lead in an often cagey fight, Froch floored the challenger towards the end of the eighth, rendering Groves unconscious.
Munster of Piper Jaffray "predicts" that AT&T will lose its iPhone exclusivity by the end of 2010, thereby rendering the company impotent and insolvent.
Managing agents and lawyers for property owners and co-op boards, however, say that the ruling places an enormous burden on building owners -- by making a legal presumption that the owner is aware of the existence of an unauthorized pet if virtually any employee or contracted worker in the building is aware of it --and can end up rendering no pet policies almost impossible to enforce.
The visualization and processing of 3D data require special navigation tools and multidimensional rendering software that are available on high end 3D rendering workstations that are most accessible in academic and specialized imaging centers.
