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Avoid text widows and orphans, i.e., words left by themselves at the end of paragraphs or single lines left at the top of columns.
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End of paragraph.
(Adds dropped quote marks at the end of paragraph 4).
Reviewer comments: At the end of paragraph 2, please explain "reasonable accuracy" in detail?
We therefore simply refer the reader to this comment at the end of Paragraph 77.
As we indicate in the Discussion (end of paragraph 1), only a few factors have been shown to determine the ultimate fate of mRNAs.
2) The authors claim (Results, end of paragraph 2) that " learned escape ceases if the quinine concentration in the test is relatively smaller than during training".
Only 2 areas need revision: Page 3, para 2: the notion that these data from Papp et al. convey is critical and the message needs an explicit sentence or two at end of paragraph.
An extra sentence has been added to the end of paragraph 1, mentioning the role of U1 snRNP in regulating cleavage and polyadenylation of mRNA (telescripting) with two references.
Page 3, para 2: the notion that these data from Papp et al. convey is critical and the message needs an explicit sentence or two at end of paragraph.
We have also modified the Discussion to point out that the substantial size of the typical 16 kb freshwater haplotype may be due to coselection for multiple phenotypes arising from linked genes, and that NAKA may be an interesting example of a population that has fixed only the armor plate changes (see the end of paragraph 5 of the revised Discussion).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com