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However, duration of the progesterone-induced [Ca2+]i transient (Δ Fmean initiation to end of falling phase) was significantly increased, from 150±8 to 284±30 s (P=0.00035; paired t test; n=11; Figure 8b).
In contrast, pre-treatment with 2-APB extended decay duration (from Δ Fmean peak to inflexion at the end of falling phase) by only 11% (from 107±7 s to 119±7 s; P=0.03; paired t test, n=16) and the absolute rate of decay was increased from 0.80±0.09 to 1.16±0.10% per second (P<0.02; paired t test, n=16 experimental pairs), consistent with stimulation of Ca2+ clearance at increased [Ca2+]i.
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