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Patients were censored at the first occurrence of an event, end of eligibility, or end of study period.
We calculated exposures from birth to death (or end of eligibility for outcome at 1 year of age) and pregnancy (gestation and each trimester) and treated exposures as time-dependent variables for subjects' exposure for each pollutant.
We calculated three types of long-term exposure: a) lifetime exposure, based on PM levels from birth to death or end of eligibility for outcome (1 year of age), b) gestational exposure (from conception to birth), and c) exposure for each trimester.
Participants were followed until the end of eligibility for Medicaid fee for service benefits, an admission to hospital of more than 30 days, their 19th birthday, death, a claim indicating pregnancy, or lack of subsequent qualifying mental health diagnosis within 24 months of the previous diagnosis.
We created time-dependent variables for cumulative lifetime exposure (from birth to death or end of eligibility for outcome at age 1 year) and for gestational exposure (for total pregnancy and each trimester) to each pollutant (TSP, PM10, PM2.5, and PM10 2.5).
The observation period started on the index date and ended at the occurrence of one of the following events, whichever was earliest: (i) AP, (ii) initiation of another new antidiabetic drug or GLP-1 receptor agonist, (iii) end of observation period and (iv) end of eligibility.
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Endings first: when the curtain fell on the opening night of "The Man Who Had All the Luck" at the American Airlines Theater on Wednesday, it was the end of Tony eligibility for the 2001-02 season, concluding a year when Broadway swooned -- and rallied -- as never before.
After 5-year survival, cohort pairs were additionally censored for death, end of OHIP eligibility or end of December 2010 for any pair member, whichever occurred first.
Patients were followed from 12 months prior to treatment initiation until the end of insurance eligibility or study end (June 30 , 2008, whichever came first.
For those patients who did not experience the microvascular event of interest (diabetic retinopathy/nephropathy/neuropathy), mean values of the last laboratory assessment prior to censorship (death, age >64 years, end of plan eligibility, or data period) are presented.
The primary endpoint was self-reported 7-day point prevalence of abstinence (PPA) at week 26 (end of coverage eligibility), defined as abstinence from smoking (not a single puff) for at least the preceding 7 days [ 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com