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In this paradigm we used a frequency of stimulation determined during the ON period, to be used at the end of dose time epoch.
We conclude that auditory stimulation may be used in order to minimize FOG at the end of dose in affected Parkinsonian patients.
This work evaluates the effect of auditory rhythmic stimulation on PD+FOG at the end of dose. 10 PD+FOG and 9 PD-FOG patients both at the end of dose periods, and 10 healthy controls were asked to perform several walking tasks.
It is known that auditory rhythmic stimulation improves gait in patients without FOG (PD-FOG), but its putative effect on patients with FOG (PD+FOG) at the end of dose has not been evaluated yet.
End of dose was defined as "deterioration and recurrence of parkinsonian symptoms as a result of shorter (sometimes only 1 to 2 hours) duration of benefit after a given dose of L-dopa".
Results from our study support the use of a frequency slightly above the preferred walking frequency (as measured during ON-periods in absence of FOG), which can then be used at the end of dose phase.
Similar(38)
Patients experiencing end-of-dose wearing-off were treated for 8 weeks (treatment phase), with an optional extension phase up to 20 weeks.
To determine the efficacy of standard levodopa combined with controlled release levodopa and entacapone in controlling end-of-dose symptoms in Parkinson's disease.
The duration of clinical control of motor symptoms of Parkinson disease (PD) treated with levodopa/carbidopa preparations eventually starts to shorten, a phenomenon known as end-of-dose "wearing off".
"end-of-dose failure" of a long acting opioid [ 35, 36].
End-of-dose phenomena in the context of GnRH analogues describe premature exhaustion of a depot formulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com