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As Western and Arab governments consider actions to stop the bloodshed — options that have been explored include more aggressive diplomacy, arming the rebels or military intervention — those discussions have been encumbered by a lack of cohesion among the Syrian opposition, evidence that some of the rebels may be affiliated with Al Qaeda and credible reports of sectarian killings.
G protein-coupled receptors (GPCRs) are the largest class of pharmaceutical protein targets, yet drug development is encumbered by a lack of information about their molecular structure and conformational dynamics.
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At trial outset, recruitment was encumbered by the lack of familiarity with and scepticism regarding this procedure in many of the centres.
Until now, genetic approaches to directly investigate patterning roles of prechordal plate, and roles for Foxa2 in this tissue, have been encumbered by lack of a prechordal plate-specific Cre line that is exclusive of other axial mesendoderm components such as notochord.
"Certainly we are encumbered by a shortage of energy".
The first HAART regimens worked in suppressing virus, but were encumbered by a variety of short term and long term side effects.
Soph, the naughty jokemistress modeled on Sophie Tucker, is reimagined here as an indomitable showgirl, encumbered by a headdress "half the size of Tennessee," in another standout segment.
(She was further encumbered by a whalebone corset and a hat the size of a flying saucer).
But the Bush administration did not want to be encumbered by a formal alliance.
Says John Collins, the NHL's chief operating officer and the man behind hockey's digital push, "We have the advantage of not being encumbered by a large national TV deal".
Now encumbered by a criminal record, these young men find themselves subject to forms of legal discrimination and permanently locked out of mainstream society.
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