Because Mr. Lechleiter, an organic chemist who is Lilly's president and chief operating officer, is a senior official about to become the chief executive, the public disclosure of an e-mail message in which he appears to have encouraged off-label promotion of Zyprexa could complicate the talks.
For instance, Kung and Lee (2001) and Shi et al. (2007) document that the development of land rental markets has encouraged off-farm employment; however, none of these studies directly analyze the impact of land insecurity on off-farm employment.
Why? Through the process of discovery, if a company's internal documents–such as sales forecast models–show that the company knew about and anticipated off-label sales, a clever prosecutor can claim that the company encouraged off-label usage.
Trials of partial breast irradiation evaluating intraoperative radiotherapy in comparison to external beam radiotherapy [ 194, 195] or brachytherapy [ 196] have short follow-up, but guidelines on partial breast irradiation [ 197, 198] have encouraged off-study use of partial breast irradiation in advance of clinical trial results.
Will he encourage off shoring of jobs and investments to avoid or limit tax liability?...or will he say that we need to grow American job opportunities?
Traffic planners sometimes mention tepid-sounding solutions like new toll systems to encourage off-peak travel or high-tech ways of alerting drivers to jams.
The changes intended to ease congestion at the crossings include variable tolls to encourage off-peak and late-night use, and discounts for E-ZPass users.
They also encourage off-balance-sheet entities, such as conduits or structured-investment vehicles, because Basel 1 allows banks to set aside less capital for these semi-detached concoctions than for assets on their books.
While doctors are free to prescribe it "off label" for any patients for any use, it would be a violation of federal law for Lilly to actively encourage off-label use of the drug.
The Port Authority of New York and New Jersey has not offered any study demonstrating that congestion pricing -- raising peak-period tolls to encourage off-peak travel -- will benefit commuters or reduce traffic congestion in Manhattan.
Peter Samuel, editor of the Toll Roads Newsletter, said people have long used out-of-state systems to pay their electronic toll bills -- particularly since some systems offer discounts to drivers to encourage off-peak travel and less-crowded highways.
