Overall our data supports a potential role for viruses in AOM, particularly HAdV, encouraging prospective studies and clinical trials to better understand the role viruses might have in endemic OM.
Given the favourable survival rate observed, the present data encourage prospective randomized studies based on this treatment strategy.
Therefore, the conduct of further prospective studies, including specific neurophysiological tests for MTT function, should be encouraged.
Further prospective studies comparing whole-body MRI and F-fluoride PET/CT, including cost analyses, should be encouraged.
Further prospective studies are warranted.
Our case series should encourage larger prospective studies to validate the described thoracic ultrasound findings in HIV-positive patients.
However, since IRE is only used as a 'last resort' curative treatment option in patients that would otherwise receive palliative chemotherapy, these early efficacy rates are promising and encourage larger prospective studies.
In conclusion, while recent publications pertaining to hybrid PET/CT scanners have been encouraging, larger prospective studies will be necessary to establish the optimal hybrid scanning protocols and to determine the precise impact in the evaluation of patients with abdominal malignancies.
In conclusion, we put forth this preliminary work in the hope it will encourage larger, multicenter, prospective studies to help determine the most appropriate pharmacologic therapy and treatment duration.
The results of our meta-analysis, which suggest a relation between Bcl-2 and survival, should encourage properly designed prospective studies, with an appropriate statistical methodology including multivariate analysis, in order to demonstrate the usefulness of molecular biological markers like Bcl-2, assessed by IHC.
