We encountered considerable difficulty when attempting to demonstrate the specificity of Tβ4 RNAi.
Nearly 95% of the complex tasks for self-management fall upon patients themselves (177), yet most patients encounter considerable difficulty in following recommended treatments and behaviors.
Although domestic production of nondurable consumer goods fosters rapid economic growth at an early stage, less-developed countries have encountered considerable difficulties in producing more-sophisticated, value-added commodities.
However, while airborne training for the first four American airborne divisions was conducted during 1943, the 13th encountered considerable difficulties when it came to its turn for training.
Under such differentials in gender, power, and social hierarchy, the participants encountered considerable difficulties and unpleasantness when communicating with their urologists.
Although the methods of implementation of Natura 2000 programme are defined by legislation and there is a possibility of benefiting from the experience of older EU Member States, in many countries the programme's implementation encountered considerable difficulties.
Nevertheless, healthcare systems in developed countries continue to encounter considerable difficulties in implementation, and experience major delays in diffusing novel initiatives, despite the perception that healthcare organisations are arguably among the most knowledge-rich and scientifically-based institutions [ 7].
Having agreed the guiding principles for a locally-appropriate SoC package for study participants through consultation with the CAC and SAG, the research team encountered considerable difficulties successfully implementing the clinical care package (Table 1) due to a combination of logistical and socio-cultural factors, in response to which a variety of corrective actions have been taken (Table 3).
Several studies have shown that chimpanzee population history can be very important for understanding the distribution of disease [ 32- 34], but these studies have encountered considerable obstacles owing to the difficulties of working with fecal samples from reclusive, highly endangered chimpanzee populations [ 32].
They encountered considerable hardship -- and danger.
