Sentence examples for encountered significant difficulties from inspiring English sources

The analysis of complex traits, including those involved in many common diseases, has encountered significant difficulties, and, despite major efforts during the past decade, has had little success.

We have recently encountered significant difficulties in processing applicants in sufficient numbers through the necessary training, vetting and accreditation procedures.

ECI agrees with the general conclusions reached by the Carter Center and others, that voters at roughly 15-20 percent of polling places encountered significant difficulties in casting their votes.

Previous studies have encountered significant difficulties in developing animal models capable of reproducing human NASH.

In trypanosomes, detailed analysis demonstrated that TbAGO1-/ mutant cells encountered significant difficulties in cell cycle progression, resulting in reduced growth rate.

We have encountered significant difficulties, such as probe cross-reactivity and non-specific product detection, using conventional methods, in assessing the specificity of Tβ4 knockdown as against a non-specific effect on its closest relative Thymosin beta 10 (Tβ10).

However, as noted in Results, we encountered significant difficulty in breeding these animals and noted a high degree of lethality early in the process.

One reason for this is because in pilot work we encountered significant difficulty in getting young children of the same age range to produce a sufficient volume of saliva necessary for the assays.

One feature of the present and Yates' [ 1] Nottingham results that is germane, is the group called 'pre-clinical' – students who encounter significant difficulties in the early part of the course, but who then progress without further problem.

This does not take into account those workers who lost their jobs in their mid-fifties and who encounter significant difficulty re-entering the workplace.

However, most of these studies to date have used either ex vivo cadaveric vessel samples or in situ euthanized animals to obtain the Micro-CT vascular maps, where the technique encounters significant difficulty in obtaining in vivo patient data.