Instead, the codon-dependent disparity primarily stems from an unusual sliding event that occurs when ribosomes encounter consecutive AAA codons.
Koutmou et al. found that when ribosomes encounter consecutive AAA codons they undergo an unusual 'sliding' movement and are unable to accurately produce proteins.
In contrast, when ribosomes encounter consecutive AAG codons, they slow down but do not slide, and therefore produce a correct protein.
Having observed no occurrence of PCP in our pediatric renal transplant unit for the last 20 years and only 1 case in all German pediatric renal transplant units during the last 10 years, we encountered 3 consecutive incidents of PCP during a 5-month period.
Table 4 summarizes frequencies of autoimmune disease encountered in two consecutive studies on the Mount Sinai Hospital CVID cohort in New York [ 3, 38] and the French DEFI cohort study [ 62].
Table 3 summarizes frequencies of specific infections and pathogens encountered in two consecutive studies on the Mount Sinai Hospital CVID cohort in New York [ 3, 38] and the French DEFI cohort study [ 4].
Additionally, seven critical unconfinement factors, each of which defines a possible transition between two consecutive configurations encountered, are also solved.
