Like NMD and NSD, No-go decay (NGD) is also translation-dependent, but it is triggered when the ribosome stalls upon encountering secondary structure in an mRNA transcript.
Additionally, symptoms of symmetric significant distal weakness with polyneuropathy would not be expected to be encountered secondary to common causes of neuropathy such as glucose dysregulation or idiopathic axonal polyneuropathies, which are characteristically sensory predominant.
When a lymphocyte recognizes an antigen, it leaves a population of memory cells (primary immune response) behind; in the second phase these memory cells respond rapidly to subsequent encounters (secondary immune response) [ 1].
Cancer cells that disseminate from primary tumors are dependent on this stromal microenvironment, and therefore the microenvironment they encounter at secondary sites determines their fate.
The article exclusion criteria most frequently encountered included: secondary validation of the scale, transcultural adaptation or translation, short form and non PRO or proxy PRO.
Instead, we recruited patients when first encountered in secondary care; this had the added benefit of recruiting patients admitted via the emergency route.
Published: November 8 , 2012Replication forks slow down when encountering DNA secondary structures, DNA lesions, and DNA-bound proteins (Mirkin and Mirkin, 2007).
