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Instead, the central region likely oscillates between two conformations, in which the coiled-coil encompasses either chains B and D or chains A and C. In both conformations, the left-handed 90° rotation would be retained; interchange between conformations would require a transitory super-helical unwinding of the central region.
These and many other cases of reductive evolution are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining.
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Uefa is offering member countries the chance to bid for two packages of matches encompassing either group stage games and a knockout round match or the semi-finals and final.
To test, if such a particular tertiary and quaternary structure of CEACAM1 might be required to allow binding of Opa protein-negative meningococci, soluble forms of CEACAM1 (sCEACAM1) that encompass either one or multiple extracellular domains were generated (Fig. 6E).
The IR-CTV encompassed either tumor extension at diagnosis or a margin (0.5 1 cm) around the HR-CTV.
A similar mechanism may be involved in the production of fused transcripts encompassing either exon 3 or 4 of PMCHL1/PMCHL2 genes.
Due to differences in definitions of outcomes assessed in respective studies, the composite endpoint in this analysis encompassed either overall, severe or nocturnal hypoglycemic events; nevertheless, only homogenous results were allowed for statistical accumulation.
The resultant statistical parametric maps were multiple comparison corrected by applying Gaussian random field theory family-wise error (FWE) correction to small volumes encompassing either occipital or temporal sensors.
The primary efficacy outcome was defined as the percentage of patients achieving target HbA1c level without hypoglycemia and encompassed either overall severe, nocturnal or symptomatic hypoglycemic events, as the definitions of outcomes varied between respective studies.
In order to explore whether the secondary structures of the RNAs were important for stabilization, we assayed a range of oligonucleotides carrying 2′-F modifications at pyrimidines, ranging in length from 19 to 121 nts, and encompassing either only a stem-loop or a mixture of base-paired and single-stranded regions.
As the definitions of the proposed subgroups encompass either antecedent and predictive characteristics (age at onset, type, and order of episodes) or antecedent and concurrent clinical syndromes (for BD-I/BD-II and history of psychosis), differentiation based on these characteristics may increase the risk for tautological conclusions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com