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This rare human disease encompasses defects in T- and B- cell maturation, cerebellar degeneration, radiosensitivity, and increased susceptibility to malignancies, especially lymphomas [ 6- 11].
The broader definition of LSDs therefore encompasses defects in the lysosomal structure and function (41) that, for less well-defined reasons, result in the accumulation of undegradable material in the endosomal/lysosomal system.
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However we have found that simply scoring a single component such as cell number does not sufficiently encompass patterning defects and fails to provide a meaningful assessment of mis-patterning.
An extensive parametric study using 2-D and 3-D numerical models was carried out encompassing different defect geometries and their interaction with pipe ovalization.
This group of defects encompasses failure of antigen-specific anergy as well as failure of non-antigen-specific 'self-control'.
Morphological defects encompassing both the ER and cell body, defective cytokinesis and nuclear segregation and internal accumulation of VSG were frequent.
The commission, which operates independently of the inspector general, countered in a statement that it "has a variety of other regulations that effectively encompass reporting all defects".
Steroid injection was effective in cases of mucosal defects encompassing the entire esophageal circumference.
We therefore designed a randomized, controlled trial to examine the efficacy of endoscopic triamcinolone injection in preventing esophageal stenoses after extensive ESD, including patients with mucosal defects encompassing the entire circumference of the esophagus.
The rectangular ROI, which encompassed the entire defect, was delineated from the adjacent bone by the clearly identifiable borders of the drill defect.
Fetal alcohol spectrum disorders (FASD) encompass the range of defects associated with prenatal exposure to ethanol.
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