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Exact(2)
(2) mRNAs encoding neurofilament subunits.
The NEFH encoding neurofilament heavy chain is one of the major components of the neuronal cytoskeleton neurofilaments [36].
Similar(58)
Jacobs cloned the gene encoding lamprey neurofilament protein and constructed complementary DNA probes that would bind to the gene's messenger RNA (mRNA) product, indicating how much protein was being made.
The genes encoding three neurofilament subunits have long been suspected as causative for ALS because of their link with motor neuron pathology in mice and humans [40].
NEFH (alias YHU2, encoding the neurofilament heavy polypeptide) possessed extreme CUB in both species.
NEFH (alias YHU2; encoding the neurofilament heavy polypeptide) possessed extreme CUB in both M. davidii and P. alecto, implying it was either present in the ancestor or has subsequently converged due to a fundamental role in both bat lineages.
NEFM is the human gene which encodes for the neurofilament medium polypeptide.
NEFM encodes the medium neurofilament protein and has been reported previously to be methylated in pancreatic cancers and astrocytoma [ 30, 31].
Our analysis reveals the alteration of two major components of the neuronal cytoskeleton in the ALS motor cortex at the mRNA level, showing a general down-regulation of microtubules by pathway-based analysis and deregulation of two genes encoding tubulin beta (TUBB2A, TUBB6), as well as decreased expression of all three neurofilament subunits (NEFL, NEF3, NEFH).
In contrast, the related Brn-3a supports survival and differentiation in neuronal cells by transactivating genes encoding anti-apoptotic proteins (e.g., Bcl-2 and Bcl-XL) and neuronal proteins (e.g., neurofilament; α-internexin; SNAP25).
Encoding events.
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