Links to customers are important in the exploratory stage of the innovation process, but encoding linkages with private and public research organisations are more important in developing innovation outputs.
Here, we show that genetically encoded linkage of CLIP and two other antigenic peptides to the HLA-DR1 α-chain results in stable complexes with inversely bound ligands.
This coding scheme has been the more common type of encoding for linkage analysis with NN [ 19- 24] 24].
In general, the PDB-style GLYCAM code uses the first character to encode the linkage position(s) (Table III), the second to encode the residue (via the character, Table II) and the isomer (via case), and the third to encode anomeric configuration (via the character) and the ring size (via case).
Both fibroblast growth factor receptor 1 oncogene partner (FGFR1OP) and chemokine receptor 6 (CCR6) are encoded by a linkage disequilibrium block located on chromosome 6q27 [[151]], and both have been identified to be associated with susceptibility of vitiligo.
HP and HPR are related and contiguous genes in strong linkage disequilibrium (LD), encoding haptoglobin and haptoglobin-related protein.
We have previously demonstrated that for DNA vaccines encoding HPV-16 E7 antigen (CRT/E7) linkage with calreticulin (CRT) linked enhances both the E7-specific CD8+ T cell immune responses and antitumor effects against E7-expressing tumors.
This general principle appears to be compatible with the detection of sporadic linkages between genes encoding HEPN domain proteins and some other dedicated phage resistance systems.
Despite a fairly detailed molecular understanding of the manner in which the AHR regulates expression of genes, such as those encoding CYP1A enzymes [ 13], the linkage between the AHR molecular mechanism and biological manifestations of TCDD-induced toxicity remain, with few exceptions [ 14- 16], elusive.
During previous work (McGary et al. 2013), we serendipitously noted the physical linkage of the genes encoding cyanase and carbonic anhydrase (a CCA gene cluster).
