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immunisations of mice with human PSMA (hPSMA) encoding DNA vaccine or protein was capable of inducing autoantibodies against native mouse PSMA (mPSMA) as demonstrated by ELISA.
For instance, a chromosome transmission fidelity (CTF) screen has identified mutations in genes encoding DNA replication, cohesion, and kinetochore proteins [16].
polA, encoding DNA polymerase I, was the key exception, as it showed weak diel periodicity with a night-time maximum (Figure 2D).
Only three such genes were detected: proteorhodopsin, blh (encoding β-carotene dioxygenase, which produces proteorhodopsin chromophore retinal) and genes encoding DNA photolyase-like flavoproteins.
This includes mutations in genes encoding DNA methylases, chromatin modifiers, and transcription factors.
FOXM1 drives the transcription of genes encoding DNA damage sensors, mediators, signal transducers and effectors.
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Three additional genes encoding DNA-binding transcriptional regulators were detected on the endogenous plasmid pCE3 of C. efficiens YS-314 (data not shown).
This analysis confirmed that the polyQ-encoding DNA sequence was also interrupted in controls, and, moreover, bore interruption patterns found among the ALS patients.
In the past, viral vectors have frequently and successfully been employed for the delivery of protein-encoding DNA sequences into living organisms.
Our genes are mosaics of protein-encoding DNA sections, called exons, separated by noncoding DNA.
Based on their study, the apoptin-encoding DNA was combined with asialoglycoprotein (Asor) to make a protein-DNA complex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com