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Eukaryotic organisms contain multiple linear chromosomes with genes that are much larger than they need to be to encode the synthesis of proteins.
Bacterial plasmids and phages encode the synthesis of toxic molecules that inhibit protozoan predation.
A large operon predicted to encode the synthesis of an exopolysaccharide was identified in strain 55730.
A neopullulanase in strain 6475, and a dextranase, L- ribulose-5-phosphate-4 epimerase (GC content of 53%), several glycosylhydrolases and hypothetical proteins (GC content between 26 29%) predicted to encode the synthesis of exopolysaccharide (EPS) in strain 55730 have been also probably acquired from other microorganisms such as Proteobacteria and other lactic acid bacteria.
Based on similarity with proteins involved in arabinosylation of the cell wall in Mycobacterium tuberculosis, noeC (AZC_3810), noeH (AZC_3809), and noeO (AZC_3808) might encode the synthesis of a D-arabinose precursor [ 50- 52].
These results suggest that DNA has the ability to control and encode the synthesis of NPs to form specific morphologies based on the DNA sequence, similar to the genetic codes for protein translation.
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In pat1, a precursor peptide encodes the synthesis of the "ascidian" natural products patellamides C and A. In pat2, the precursor peptide encodes the products patellamides C and ulithiacycliamide (in place of patellamide A).
Genome-wide analysis revealed that the genome of the immunostimulatory strain 55730 encodes the synthesis of putative compounds (EPS, cell surface protein containing five repetitive Rib motifs) that can be pro-inflammatory.
Thus, the demonstration here that the control of genes encoding the synthesis of MR and DC-SIGN, as two key endocytic receptors [41], is affected by ECM components is a novel observation and one that highlights the importance of incorporating ECM in studies of DC cultures and DC-T cell co-cultures.
Moreover, genes encoding the synthesis of the F420 coenzyme, an important electron carrier in methanogens, are also absent.
It has even been reported that psychotropic drugs modify the expression of genes encoding the synthesis of tachykinin in some areas of the rat brain [ 133, 134].
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