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In that case, a floxed gene was deleted by 4OHT-activation of Cre recombinase, thereby enabling the consequences of gene deletion to be studied after replating the cells.
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This work marked a major step forward in our understanding of evolution, for it enabled the consequences of various evolutionary hypotheses to be explored quantitatively rather than just qualitatively.
The availability of a large series of human fetuses including 14 ACH and 26 TD enabled the consequences of FGFR3 mutations on endogenous receptor expression during the prenatal period to be assessed by analysis of primary cultured chondrocytes and cartilage growth plates.
Secondly, loss of Hedgehog function in the developing dorsal CNS creates severe phenotypes which have made interpretation difficult when superimposing other genotypes, and the gain of Hh function phenotype we define here has enabled the consequences of concomitant loss of Notch function to be readily assessed.
By chaperoning calcineurin, Hsp90 regulates membrane stress responses that are crucial for cells to survive azole exposure, thereby enabling the phenotypic consequences of new resistance mutations.
Most importantly, this enables the possible consequences of therapeutic efforts directed against either proliferative slender forms or transmission blocking strategies targeting intermediate and stumpy forms, to be predicted and control measures optimized.
These have enabled evaluation of the consequences of prostate-specific expression of genes implicated in human prostate cancer.
Another advantage of the methodology described in this study is that it enables evaluation of the consequences of proteolytic events from the abundance of various proteolytic fragments from the same protein.
Encouraging children to take a holistic approach and enabling them to understand the consequences of their actions provides them with skills in the future to best handle unanticipated consequences.
Advocates believe that community involvement can make health services more accessible and sustainable, and that enabling communities to explore the consequences of health behaviour can yield lasting improvements in health outcomes.
This enables us to explore the consequences of various different selective regimes.
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