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In general, TFs (including OSK) are known to reshape the chromatin landscape in the regions where they bind, both by enabling the binding of other TFs and through direct recruitment of various histone modifiers (Mal & Harter, 2003; Ancelin et al, 2006; Magnani et al, 2011; Zaret & Carroll, 2011; Soufi et al, 2012; Drouin, 2014; Sherwood et al, 2014) (Fig 1A).
Conclusion: We have developed a family of nanoparticles based on degradable, biocompatible and functionalisable polymers, enabling the binding of specific targeting agents (eg. peptides) and incorporating an imaging agent, either for optical or scintigraphic imaging.
These mesosensor responses can be triggered by the target species and can transduce measurable optical signals under synergistic pH conditions, thus enabling the binding of Fe3+ and Hg2+ metals into a hydrophobic chelating pocket to be simulated.
Activated JAK immediately phosphorylates the receptor complex, enabling the binding and subsequent phosphorylation of cytoplasmic STAT.
This should be beneficial in the application of membrane-active peptides since efficiency can be increased by enabling the binding of a larger amount of peptides per cell (Zwaal and Schroit, 1997; Papo and Shai, 2005).
These were derivatized with aminobutylnitrilotriacetic acid, and complexed with Ni2+, enabling the binding of histidine-labeled green fluorescent protein, which yielded bright fluorescence from 70-nm-wide lines that could be imaged clearly in a confocal microscope.
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However, structural alignments and three-dimensional modeling illustrated several elements common to LI818 proteins, which are likely to interfere with their capacity to bind certain chlorophyll b molecules, but may enable the binding of chlorophyll c and/or fucoxanthin.
Internal cavities in proteins produce conformational fluctuations and enable the binding of small ligands.
This paralog has been hypothesized to display structural features that enable the binding of the bulkier precursors required for the biosynthesis of lepidopteran ethyl-branched JHs.
The stability of the best enzyme was then increased by semirational mutagenesis, after which its active site was rationally engineered to enable the binding of polyphenolic acceptors.
The strong binding of pembrolizumab to hPD-1 and avelumab to hPD-L1 would enable the binding priority of the therapeutic antibodies with checkpoint molecules and subsequent blockade of the hPD-1/hPD-L1 interaction.
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