Exact(2)
Here we suggest that it is direct linkage between self and foreign antigen recognition that produces the necessary blend of TCR diversity and specificity in the mature peripheral repertoire, enabling responses to a broad universe of unpredictable antigens while maintaining an adequate number of highly sensitive T cells in a population of limited size.
However, there is still work to be done to identify a biomarker that truly reflects disease activity and progression, as well as enabling responses to ERT to be measured.
Similar(58)
Events provide well-defined hooks enabling response actions to occur.
Three patients had non-evaluable disease at baseline hence not enabling response assessment using RECIST criteria.
Most importantly, it is a school improvement process involving the active participation of parents and the wider community, together with students and teachers, enabling response to the needs of specific children within specific communities.
During wound closure, the same events may actively contribute to the wound epithelial advance with a 'pushing' force or, rather, may be a passive, enabling response to the actomyosin cable contractile forces from the front row cells.
The current data suggest that even minor alterations in SOD3 expression significantly affect SOS1 and SOS2 GEF expression via a feedback loop, hence enabling response to sudden changes in signaling and fine adjustments of SOD3 production.
Asymmetric feedback on CqsS enables responses exclusively to the CAI-1 autoinducer.
However, this method is expensive, time-consuming and does not enable responses to changes in raw water quality in real time.
We will shortly enter into a second comment period designed to enable responses to previously submitted notes.
Bypassing this requirement enables responses to extracellular self nucleic acid and leads to fatal inflammatory disease in mice (Mouchess et al., 2011).
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