Supporting this, Ku80 knockout restores the viability of Lig4 −/− mice (Karanjawala et al, 2002), thus enabling repair of the DSBs accumulated in the absence of LIG4.
This stitch is likely to improve healing rates and safety, as well as to enable repair of tears that were previously considered difficult or impossible to sew.
Thus, SMARCAL1's function is vital to efficiently reset the DNA replication fork to enable repair of fork-stalling lesions.
The 5′ ends of the primers included 18 nt extensions identical to plasmid sequences flanking the intended insertion site, to enable repair of gapped plasmids by homologous recombination.
The 5′ ends of the primers included 18 nt extensions homologous to plasmid sequences flanking the intended insertion site, to enable repair of gapped plasmids by homologous recombination.
The 5′ ends of the primers included 18 nucleotide extensions, homologous with plasmid sequences flanking the intended insertion site, to enable repair of gapped plasmids by homologous recombination.
Recently, several readthrough compounds have been shown to enable repair of UV damage in xeroderma pigmentosum (XP) cells (Kuschal et al, 2013).
Since numerous tissue types require the support of stromal fibroblasts to provide appropriate cross-talk and ECM production to maintain tissue homeostasis and enable repair, the fibroblast cells that we derived have great potential for applications in regenerative medicine [35].
However, in recent years, it is being increasingly recognized that, in individual cells, there are graded responses collectively termed cell-autonomous defense mechanisms that induce cellular processes designed to limit cell damage, enable repair, and eliminate bacteria.
Infections are compartmentalised by localised physiological responses, and multiple apical meristems enable repair and regrowth, but genes are another crucial component in the perception and response to pathogens.
