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With a highly enabling method for the formation of C3 C3′ bonds in hand, dimeric diketopiperazines -WIN 64821 (31) and -ditryptophenaline (33) provided optimal platforms for exploring the synthesis of diketopiperazines, evaluating their stereoselectivities in halocyclization, managing their proclivity for epimerization, and verifying their compatibility with the dimerization conditions (Scheme 4).
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The enabling methods for advanced interceptors to achieve the hit-to-kill accuracy against targets performing evasive maneuvers including spiraling motion are developed on the basis of one unified theory for the purpose of design and analysis, viz. a contemporary nonlinear robust control theory such as the sliding mode control.
The aim of the study was to develop a virtual microscopy enabled method for assessment of Ki-67 expression and to study the prognostic value of the automated analysis in a comprehensive series of patients with breast cancer.
Modern computers enable methods for design optimization that account for uncertainty in the system so-called optimization under uncertainty (OUU).
Therefore, electrochemically assisted electrospray ionization enables method development for the identification of SEL and its potential metabolites by means of HPLC/ESI-MS.
Results promote the knowledge on growth mechanism and kinetics of anodic films enabling methods to optimise the structure for their many scientific or technological applications.
This methodology not only enables an integrated framework for evaluating dynamic performance and reliability of fault-tolerant systems, but also enables a method for guiding the system design process, and further optimization.
Thus, the high selectivity of ZnO nanosheets enables the method for accurate and precise determination of Cd II) in complex matrices.
The two-part protocol design was chosen to promote flexibility in the protocol, enabling other methods for, or skipping of, the size selection step.
19 Progress in microsurgery has enabled new methods for investigating the lymphatic system.
The feature is a key one for Apple's ability to reach an even wider range of customers with its digital content stores – enabling a simpler method for iTunes account top-ups means that the company can better serve its customers who either aren't able or don't want to use credit cards to automatically transfer funds to their account.
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