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Transcription activator-like effector (TALE) proteins present a powerful tool for genome editing and engineering, enabling introduction of site-specific mutations, gene knockouts or regulation of the transcription levels of selected genes.
Gene flow has occurred to and from other such populations enabling introduction of new adaptive variation and potentially both enhancing and limiting local adaptation, depending on local selection regimes and migration-drift-selection equilibrium [ 24, 25].
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This capability would enable introduction of a Europe-wide road pricing system, on a miles travelled basis, which the EU Transport Commissioner is keen to introduce.
This intermediate enabled introduction of an amino group at C12 stereospecifically and in high yield.
Therefore, alternative vaccine delivery systems, which enable introduction of nonreplicating antigen into the MHC class I presentation pathway, are sought.
Lowercase letters: deviations from the original OsRpl6-1 sequence to enable introduction of restriction sites.
The absence of any paternal or zygotic effects enabled introduction of enhancer lacZ reporters into the atlas (see Materials and Methods; supplementary material Table S1).
ES cell-based targeting technology enables introduction of subtle genomic modifications, but it is a lengthy process involving multiple steps (reviewed by Menke 2013).
This approach allows mixing-and-matching of specific functional amino acid sequences from the different families of collagens and enables introduction of non-native sequences at defined locations, combinations, and number of occurrences [ 2].
Mass gatherings enable introduction of novel influenza strains into the local population and the amplification of circulating local seasonal influenza strains, or both, thereby increasing the opportunity for novel reassortment influenza viruses to emerge.
In addition, immunostaining against GFP visualized cells exhibiting morphology typical of oligodendrocytes, suggesting that the Tol2 transposase enables introduction of transgenes into both astrocyte and oligodendrocyte lineages by in utero electroporation (Fig. 4F and see also Fig. 2G) (Zerlin et al. 2004).
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