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In summary, in this study we describe a novel computational model of epidermal wound healing, based on previously published experimental work both at the cellular and sub-cellular levels, enabling hypotheses to be readily generated and tested.
In-silico experiments were conducted by changing parameters, enabling hypotheses and predictions about the process to be tested.
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Controlled, three-dimensional (3D) cell culture systems are of growing interest for both tissue regeneration and disease, including cancer, enabling hypothesis testing about the effects of microenvironment cues on a variety of cellular processes, including aspects of disease progression.
Then one builds confidence intervals, and computes estimates of variation enabling hypothesis testing.
This computational approach potentially revealed the complex interplay of functional interactions between proteins involved in S. meliloti-Medicago symbiosis providing a way to expand the current understanding of symbiosis by enabling hypothesis generation based on our predicted network.
There is a need for a fast easy-to-use exploratory tool that can use phylogenies constructed with any of the most popular methods, while providing fast inference of ancestral traits and enabling hypothesis testing and visual data interpretation of evolutionary scenarios.
They provide a concise description of complex dynamic processes, indicate ways in which improved experimental design could be achieved, and enable hypotheses concerning physiological structure to be tested.
This enabled hypotheses generation and an identification of transcription factors acting on such a promoter set with the ultimate goal to identify "molecular triggers" in gene regulatory networks forcing hepatocytes into malignant transformation.
The population structure also enables hypotheses concerning the prehistoric spread and development of agriculture to be addressed.
This enables hypotheses such as 'the level of the series rose briefly' to be modeled, as opposed to hypotheses such as 'the level of the series rose, and declined exponentially to pre-intervention levels'.
In addition, comparing cell- and tissue- specific transcription profiling studies (e.g [ 33]) in non-diseased settings would enable hypotheses to be made about which cells are changing early in glaucoma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com