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Gerald Fink, professor, biology; member, Whitehead Institute: Compound to enhance immune stimulation--A compound to stimulate a more powerful immune response to specific monoclonal antibodies, potentially enabling development of effective new disease therapies.
There is no crystal structure available for S. aureus PheRS, therefore comparative structure modeling is required to establish a putative 3D structure for the required enzyme enabling development of new inhibitors with greater selectivity.
These non-invasive tools will also promote the clinical development of antifibrotic drugs, by permitting the design of lean proof-of-concept studies, and enabling development of a personalised antifibrotic therapy for patients with rapid fibrosis progression or advanced disease.
A wide range of optical bandgap modulation up to 5.1 eV was achieved for quaternary BeMgZnO thin films prepared using plasma assisted molecular beam epitaxy, enabling development of UV emitters and solar-blind photodetectors.
The design of uprights is currently based on experimental or high-end computational methods, but analysis based-design involves lesser design office effort enabling development of innovative and optimized sections.
Geometry has been a source of inspiration in the design of the manmade world for millennia; it also provides representational means enabling development of a concept into a built object.
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The fund serves to enable development of projects that intersect across disciplines and geographies.
Highways also enabled development of new suburban housing to serve those preferences.
This enables development of efficient and effective computational schemes, such as the FFT.
Larger longitudinal data sets have enabled development of composite outcome measures and more stringent standards for disease control.
The application of CRISPR/Cas9 is likely to enable development of purpose-built gene drives in the next few years.
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