In that case, a floxed gene was deleted by 4OHT-activation of Cre recombinase, thereby enabling the consequences of gene deletion to be studied after replating the cells.
This work marked a major step forward in our understanding of evolution, for it enabled the consequences of various evolutionary hypotheses to be explored quantitatively rather than just qualitatively.
The availability of a large series of human fetuses including 14 ACH and 26 TD enabled the consequences of FGFR3 mutations on endogenous receptor expression during the prenatal period to be assessed by analysis of primary cultured chondrocytes and cartilage growth plates.
Only then can the biological information be used in conjunction with models of predicted change in the region to enable any consequences for biodiversity to be predicted.
Secondly, loss of Hedgehog function in the developing dorsal CNS creates severe phenotypes which have made interpretation difficult when superimposing other genotypes, and the gain of Hh function phenotype we define here has enabled the consequences of concomitant loss of Notch function to be readily assessed.
In addition, as argued throughout the manuscript, the regret formulation may have additional decision-theoretical advantages as it enables experiencing consequences of decisions both at the emotional (system 1) and cognitive (system 2) level[ 23, 40].
This often leads to a problematic socioeconomic situation for which sex work or transactional sex are common consequences, enabling transgender women to remain resilient in the context of poverty.
This suggests that serelaxin may regulate reparative fibrosis without adverse consequences, enabling subsequent myocardial healing.
By chaperoning calcineurin, Hsp90 regulates membrane stress responses that are crucial for cells to survive azole exposure, thereby enabling the phenotypic consequences of new resistance mutations.
25 The economic evaluation will estimate the difference in the cost of resource inputs used by participants in the two arms of the trial, allowing comparisons to be made between the two surgical treatment options (intramedullary nail vs 'locking' plate fixation) for patients with a displaced, extra-articular fracture of the distal tibia, and enabling costs and consequences to be compared.
