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γH2AX enables the binding of additional DDR factors, such as MDC1, BRCA1, and 53BP1.
For this case the plasticity of the disordered region clearly enables the binding to multiple partners.
The phosphorylation by TOR in turn enables the binding of active PDK1 [ 77] to the C-terminal motif.
It is thought that this hypomethylation enables the binding of the insulator protein CTCF to the paternal allele.
Phosphorylation by DAPk leads to dissociation of Beclin 1 from its inhibitors Bcl-2/Bcl-XL and this presumably enables the binding to and activation of Vps34.
In vertebrates, Smc3 acetylation enables the binding of sororin to Pds5, which counteracts Wapl's ability to remove cohesin from chromatin [ 17- 19].
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In general, TFs (including OSK) are known to reshape the chromatin landscape in the regions where they bind, both by enabling the binding of other TFs and through direct recruitment of various histone modifiers (Mal & Harter, 2003; Ancelin et al, 2006; Magnani et al, 2011; Zaret & Carroll, 2011; Soufi et al, 2012; Drouin, 2014; Sherwood et al, 2014) (Fig 1A).
However, structural alignments and three-dimensional modeling illustrated several elements common to LI818 proteins, which are likely to interfere with their capacity to bind certain chlorophyll b molecules, but may enable the binding of chlorophyll c and/or fucoxanthin.
Internal cavities in proteins produce conformational fluctuations and enable the binding of small ligands.
This paralog has been hypothesized to display structural features that enable the binding of the bulkier precursors required for the biosynthesis of lepidopteran ethyl-branched JHs.
The stability of the best enzyme was then increased by semirational mutagenesis, after which its active site was rationally engineered to enable the binding of polyphenolic acceptors.
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