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The side effects associated with anticancer drugs can be reduced through the use of multiple agents, which often enables the administration of lower dosages of each drug.
Percutaneous isolated hepatic perfusion (PIHP) is a form of high-dose regional chemotherapy that enables the administration of cytotoxic agents at a dose of up to 10 times the maximally tolerated dose, while reducing exposure of the entire body to the major adverse effects of the therapeutic agents [10].
This enables the administration of high radiation doses, reported to offer excellent clinical results similar to radical surgery for early stage NSCLC [ 9, 10, 18].
Although oral iron is less expensive, easier to administer, and may be safer, IV iron enables the administration of larger doses of iron and is better tolerated by some patients [ 11].
The embedding of flurbiprofen into nanoparticles not only disguises its cytotoxic potential, it further enables the administration of higher drug concentrations resulting in a sufficient transport of the drug across the endothelial cell monolayer.
The drug can be directly absorbed into the systemic circulation through the highly vascular oral mucosa and therefore avoid hepatic first-pass metabolism which enables the administration of a lower dose, thus minimizing the adverse effects related to the drug molecule [ 12].
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Percutaneous catheterization of the coronary sinus (CS) to enable the administration of retrograde cardioplegia may play an important role in minimally invasive cardiac surgery.
Next, we tested whether this early detection would enable the administration of treatment (ie, interleukin-1 receptor antagonist [IL-1Ra]) in a realistic clinical time after diagnosis.
All subjects were placed in a semi-recumbent position enabling the administration of hypoxia to participants.
More work is needed to further enable the administration of an effective feedback system in healthcare settings.
The preparation of oral paliperidone adopts a drug-delivery control system that uses osmotic pressure, enabling the administration of treatment once a day [ 14].
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