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We exploit a double-transgenic zebrafish that enables simultaneous analysis of cytoplasmic changes in Ca2+ and of overall changes in cell morphology, and extend our analysis of Ca2+ regulation in pde6c w59 cones to the commonly studied rd1 mouse model.
To quickly, efficiently, and simultaneously detect large numbers of LOH and CNV events in C. albicans, we designed and constructed a custom microarray including ∼39,000 SNP alleles (2 SNP alleles/locus) plus ∼20,000 CGH (non-SNP) loci (see Materials and Methods for details) using the Agilent custom array format, which enables simultaneous analysis of eight sets of 60,000 probes.
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By enabling simultaneous analysis of numerous genes in single neural crest cells in vivo, SGA reveals previously unknown position based differences in gene expression among premigratory and early migrating cranial neural crest cells.
SGA was developed by combining sequential single molecule fluorescence in situ hybridization (seqFISH 13,14,15 with hybridization chain reaction (HCR 16,17,18 to amplify signal strength for in vivo tissue applications, thus enabling simultaneous analysis of multiple transcripts on embryonic tissue sections.
Here, we use multiple logistic regression models enabling simultaneous analysis of all included alleles while adjusting for the potential confounding effect due to LD [12].
The use of pharmacokinetic pharmacodynamic (PKPD) models can enable simultaneous analysis of both longitudinal biomarker and survival data.
To enable simultaneous analysis of tissues using the same reaction, tissue microarrays were used for immunohistochemical studies.
Fluorescence was captured from cells in the same microscopy field-settings as for LC3 determination, enabling simultaneous analysis of LC3 fluorescence and TP53 signals in 50 individual cells.
Analysis of genome-wide methylation profiles by new high-throughput technologies which enable simultaneous analysis of thousands of genetic loci will certainly help to identify highly specific novel methylation biomarkers.
Technologies that enable simultaneous analysis of thousands of SNPs have permitted genome-wide association studies for complex traits in humans [ 2], chicken [ 3], cattle [ 4- 6] and sheep [ 7].
The gray matter underlying the planum temporale was manually segmented using interactive mouse driven software (Display, Montreal Neurological Institute, Canada) that enabled simultaneous analysis of coronal, sagittal and axial slices.
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