The main limitation of the evaluation was the lack of time and funding to enable more extensive community feedback and verification of the findings.
The existence of an outgroup of nitrogenase homologs (termed Group IV) has been noted previously [ 27], but the current availability of genome sequences has enabled more extensive analysis.
Indeed, the comprehensive phenotyping of mutants, which is a common practice in mice [ 4] for example, has begun in quail [ 5, 6], but more contributions are needed to enable more extensive comparisons between mammals and birds.
More recently, the use of genome-based approaches has enabled more extensive investigations of sources of systematic bias, or inconsistency in phylogenetic analyses [ 102, 106- 108] and identified new effects difficult to detect in smaller data sets, such as site-specific changes in evolutionary rates among lineages, or heterotachy [ 109- 111].
While this method does not account for binucleation, as described by Walsh et al. (21), it has the advantage of enabling more extensive coexpression analyses, while still demonstrating relative proportions of cell types and changes in them, if not absolute numbers in individual hearts.
The close working relationship allows Nokia to better utilize the map data that NAVTEQ supplies, which provides a higher quality and extensive coverage that enables more effective location based experiences.
We are aware that RNA-Seq enables a more extensive profiling of the transcriptome by facilitating the discovery of fusion genes [ 20], detection and quantification of alternative splice forms, and characterization of expressed mutations and polymorphisms [ 14].
We are currently developing extensions to increase the computational speed of LOCate, which will enable a more extensive range of simulations to compare LOCate's performance to LOT on a variety of ordinal and nominal traits with varying amounts of missing data and inbreeding.
