In plasmonic nanomaterials, nanostructuring of metallic systems enables localization of light in very small volumes with a concentration of light (fields) at the resonant frequency16.
Array CGH enables localization of genomic aberrations in tumors, identification of critical genes, and classification of chromosomal changes [ 1], indicating susceptibility or activation of tumor initiation and progression [ 19].
This approach also enables localization of the same positions on samples after repeated mounting in various microscopes with a precision better than 50 nm.
It also enables localization, context awareness and mobility support [49].
Attachment to targeting ligands enables localization by PET and NIRF.
Images were acquired at stages indicated in panel A. DOI: http://dx.doi.org/10.7554/eLife.02203.009 Recent advances in fluorescence microscopy enable localization of molecules in live and fixed cells with sub-diffraction accuracy (Sengupta et al., 2012).
Raman observations were confirmed by scanning electron microscopy (SEM) and X-ray elemental analyses, which enabled localization of individual nanoparticles embedded in tumor tissues.
However, the CLSM used in the present study enabled localization of the exact position of signal-positive cells in the blastocoel with superb resolution (Fig. 6C H).
21– 24 Methods that enable localization and direct visualization of NMJs in situ may therefore facilitate analysis and interpretation of EMG, without recourse to an invasive motor-point biopsy, and may also improve the targeting and efficacy of potential treatments.
Finally, to enable localization of the SN and VTA in the midbrain, a proton-density weighted image (TR/TE 6,000/16 ms, FA 149 deg, echo spacing 15.6 ms, 0.75 × 0.75 mm voxels in-plane) was acquired using the slice center and orientation information from the functional images (Oikawa, Sasaki, Tamakawa, Ehara, & Tohyama, 2002).
