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The population structure also enables hypotheses concerning the prehistoric spread and development of agriculture to be addressed.
This enables hypotheses such as 'the level of the series rose briefly' to be modeled, as opposed to hypotheses such as 'the level of the series rose, and declined exponentially to pre-intervention levels'.
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Experimental use of animal models enables hypothesis testing under controlled conditions that are often not possible in clinical research.
Mapping of biological and other information to network nodes or edges enables hypothesis creation about sequence structure function relationships across sets of related proteins.
We show that conceptualizing existing knowledge on kinase regulatory motifs in a machine readable format provides useful context for predicting variant impact, allows rapid comparisons of protein kinase sequences and structures across the kinome and enables hypothesis generation and reasoning over existing data.
They provide a concise description of complex dynamic processes, indicate ways in which improved experimental design could be achieved, and enable hypotheses concerning physiological structure to be tested.
This enabled hypotheses generation and an identification of transcription factors acting on such a promoter set with the ultimate goal to identify "molecular triggers" in gene regulatory networks forcing hepatocytes into malignant transformation.
In summary, in this study we describe a novel computational model of epidermal wound healing, based on previously published experimental work both at the cellular and sub-cellular levels, enabling hypotheses to be readily generated and tested.
In-silico experiments were conducted by changing parameters, enabling hypotheses and predictions about the process to be tested.
In addition, comparing cell- and tissue- specific transcription profiling studies (e.g [ 33]) in non-diseased settings would enable hypotheses to be made about which cells are changing early in glaucoma.
PMA was developed to overcome some of the problems of normal (retrospective) meta-analyses, mainly to enable hypotheses to be specified a priori and ignorant of the results of individual trials.
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