Overall, there were no notable differences between the two CZP dosing regimens in the overall axSpA population or either subpopulation, enabling dosing flexibility and the convenience of less frequent dosing in some patients.
The linac is a Siemens Oncor without a flattening filter, and enables dose rates to reach 1000 monitor units (MUs) per minute.
The modified Tactipen® used in EDITION 3 allowed smaller increment steps (1.5 U) compared with the modified SoloSTAR® pen (3 U), to enable dosing for an insulin-naïve population with a wide range of insulin requirements.
The addition of prophylactic antibiotics enabled dose-escalation to 275 mg/m2 without reaching MTD.
Geron has been undertaking studies to enable dose escalation of its spinal cord injury product, and has been investigating application of the product to other neurodegenerative diseases.
Our automated control platform is an innovative tool to enable dose-response studies of small molecules and investigation of gene dosage effects in disease.
Biotin-inducible transgene expression was functional in a variety of rodent, monkey and human cell lines, showed excellent adjustability and reversibility in transgenic Chinese hamster ovary cell lines, provided precise product gene control in standard bioreactor cultures and enabled dose-dependent vitamin H control of a human glycoprotein in mice.
Technological innovations enable dose reduction, thus lowering the chance of adverse effects.
The results highlight how IRIS may offer a superior balance between image quality and dose across a range of imaging tasks, thus enabling dose reduction at constant quality or image quality improvement at constant dose.
Additionally, with regard to planning procedures for radiotherapy, the use of FDG-PET for target volume definition may enable dose escalation, a lower exposure of organs at risk, as well as reduced interobserver variability [6, 7].
