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The linac is a Siemens Oncor without a flattening filter, and enables dose rates to reach 1000 monitor units (MUs) per minute.
Improved target conformity, particularly for concave target volumes Can produce intentional dose inhomogeneity dose-painting inhomogeneity dose-paintingrIncreaseses dose escalationormalcompensatissue misparingissuEnables
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As an oral agent, capecitabine enables dosing that approximates to continuous infusion 5-FU with improved convenience.
Geron has been undertaking studies to enable dose escalation of its spinal cord injury product, and has been investigating application of the product to other neurodegenerative diseases.
Technological innovations enable dose reduction, thus lowering the chance of adverse effects.
The results highlight how IRIS may offer a superior balance between image quality and dose across a range of imaging tasks, thus enabling dose reduction at constant quality or image quality improvement at constant dose.
Additionally, with regard to planning procedures for radiotherapy, the use of FDG-PET for target volume definition may enable dose escalation, a lower exposure of organs at risk, as well as reduced interobserver variability [6, 7].
Prostate radiotherapy has also evolved with these technological advancements, enabling dose escalation.
Hyperfractionation is simply the tool to enable dose escalation without an increase of severe late toxicity.
Identification of (causal path) biomarkers could enable dose optimization and monitoring of response based on the changes in levels.
Examining consistency of effect across multiple clinical endpoints in a proof-of-concept study may identify efficacious therapies and enable dose selection for confirmatory trials.
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