Constitutive overexpressions of pca gene clusters enabled wild-type C. glutamicum to tolerate oxidizing stressors, and pcaHGBC expression was the most effective among pca gene clusters (Figures 2 and 3).
Furthermore, anti-PD-1 monotherapy enabled wild-type mice to block tumor growth to similar levels as SKAP55-deficient mice (Fig 6C, green vs. purple lines).
The expressions of pca gene clusters also enabled the wild-type to increase its resistance against oxidative stressors, such as diamide and cumene hydroperoxide, as well as H2O2.
RIP1-Tag2 positive (RT2) HRG heterozygote (HRG+/−) males were mated with RIP1-Tag2 negative HRG+/− females to enable analysis of HRG wild type (HRG+/+) and HRG knockout (HRG−/−) littermates in a RT2 positive genetic background.
Wild type: enables the user to browse all muteins and their reactions for a defined wild-type enzyme.
Comparison of each mutant with the wild type strain enabled us to identify the sncRNA GcvB as a previously unknown regulator of AR in E. coli.
Incorporating additional data, mainly from trials that recruited only patients with wild type EGFR, enabled us to provide further evidence that TKIs are inferior to chemotherapy as second-line treatment in patients with wild type EGFR, reducing median PFS by approximately 3 weeks.
acaA mutant cells do not aggregate but the addition of extracellular cAMP or of 2' deoxy cAMP, that does not activate protein kinase A, or the presence of wild type cells, enables aggregation of the mutant cells.
A comparative set of mutant measurements relative to wild type control measurements enabled t-statistics and p-values to be calculated [ 13].
In contrast to the oligonucleotide-mediated gene targeting with wild type Cas9 that enables homozygous targeting of both alleles, no homozygous knock-in clones were identified in this study.
Therefore, the independent regulation of both PilC variants in wild type bacteria could enable meningococci to sequentially modulate host cell response in a controlled manner, with partially overlapping (i.e. cellular binding) and partially antagonising (i.e. depletion of EGFR pool and motility) effects, depending on the cellular diversity of each ecological niche.
