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In vitro transcription assays and measurements of promoter activity using the overexpression of a single sigma factor gene and the transcriptional fusion of the promoter to the gfpuv reporter gene enabled us to reliably define the sigma factor dependency of promoters.
The MeDIP procedure combined with CGI microarray technology enabled us to reliably and efficiently profile the methylation states of a wide range of CpG islands in multiple samples.
These important design features enabled us to reliably train and test a classifier and to dissociate the multi-voxel patterns of both schema components (rule-based associations, low-level visual features).
A validated statistical model enabled us to reliably predict that from 2010 to 2025 the number of new cases would reach 46,600, with an evident downward shift in the age of onset.
The utilization of the dual-luciferase imaging approach enabled us to reliably quantify the magnitude of down-regulation of histone methylation in tumor tissue induced by treatment of mice with histone methyltransferase inhibitors in vivo.
By training and testing subjects on schema material across consecutive days, we achieved near-ceiling performance that enabled us to reliably train and test a classifier and to dissociate the multi-voxel patterns of both schema components (rule-based associations, low-level visual features).
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To answer this question, we selectively expressed a conditional form of ChR2 in cholinergic neurons of the dorsal striatum, enabling us to reliably evoke action potentials in CINs.
Use of different computational approaches enables us to reliably recognize distant relationships, especially when they converge to a common assignment because the methods are often complementary.
This background image was then subtracted from the original image, which enabled us to visualise and reliably quantify spots that were marginally above the background value and in that way fully utilise the dynamic range.
Laser microdissection and subsequent RAP-PCR reliably enabled us to obtain novel insights into the area-dependent differential regulation of gene expression in human RA synovium and distinction between different cell types.
Applying the SS-approach (26, 32) enabled us to develop a complex program that was able to reliably reveal latent periodicity regions of differing types (approximate tandem repeats, fuzzy repeats, profile periodicity).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com