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Incubation of triplicate reactions in the presence of a range of inhibitor concentrations enabled determination of a dose-response for enzyme inhibition by the test compound and calculation of an IC50 value.
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Combined with biochemical fractionation of the total COD of substrates, this method enabled determination of an ADM1-consistent input state variable set for each substrate with affordable identifiability.
The model tablets enabled determination of an appropriate binarization threshold for assessing the mean particle size of micrometer-scale API in tablets by utilizing the unique physicochemical properties of polystyrene microspheres.
A set of FEM models created on the base of Abbot-Firestone curves, determined from the roughness profile, enables determination of a contact surface stiffness curve and further the interference correction.
These advances enable determination of a cryo-EM density map for β-galactosidase bound to the inhibitor phenylethyl β-D-thiogalactopyranoside where the ordered regions are resolved at a level of detail seen in X-ray maps at ∼ 1.5 Å resolution.
These advances enable determination of a cryo-EM density map for β-galactosidase bound to the inhibitor phenylethyl β-D-thiogalactopyranoside where the ordered regions are resolved at a level of detail seen in X-ray maps at ∼ 1.5 Å resolution.
This was done to enable determination of a survival trend in the two sets of restorations and to assess a restoration survival difference per year of evaluation.
Analysis of the current results did not enable determination of a critical threshold of increase predicting ROSC with acceptable specificity/sensitivity. Probably, larger patient numbers will be needed and our ongoing multicenter trial (ClinicalTrials.gov NCT01806844) could enable us to analyze whether this critical threshold for rSO2 increase can be determined.
Recent technological developments have enabled determination of DNA trajectories in a few DNA-loop-containing regulatory complexes.
The corresponding primer sets are listed in Additional file 4. Cloning and sequencing of the PCR amplicons of remnant mRNAs enabled determination of the nucleotide position when a slicing event occurred.
The full-length genome sequence of yam chlorotic necrosis virus was determined using Sanger sequencing, which enabled determination of the coverage and sequencing accuracy of the MinION technology.
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