As with all ALMPs, targeting plays a crucial role in enabling cost-effectiveness, and detailed rules should minimize caseworkers' leeway.
A simple economic evaluation of the relative costs of the diagnostic tests will be included to enable cost-effectiveness modelling.
The inclusion of these clinical, utility and cost measures at baseline and follow-up will enable cost-effectiveness and cost-utility analyses to be carried out (see below).
5) A comprehensive cost database for each diagnostic approach will be developed to enable cost-effectiveness modelling of the optimal strategy.
Probabilistic sensitivity analysis (PSA) (1,000 iterations) was used to model joint parameter uncertainty, enabling cost-effectiveness acceptability curves (CEACs) to be calculated.
Our results allow conclusions to be made about the value of preference for a certain state versus another state enabling cost-effectiveness and cost-utility estimations using cost per QALY gained.
Generic measures may not be sensitive enough to fully capture the QoL effects for certain populations, such as carers, so there is a need to consider additional outcome measures, which are preference based where possible to enable cost-effectiveness analysis to be undertaken.
Although this unit is not an ideal effectiveness unit [ 52] and requires assessment of utilities, which for some chronic wounds can be a challenge, it does enable cost effectiveness of studies to be compared against each other.
These costs are not often included in economic evaluations for chronic disease and use in future research will enable cost effectiveness studies to take a broader societal perspective as compared to a narrow health system perspective.
Combined with quality of life and drug use data, this enabled a cost-effectiveness study based solely on direct observations, something not previously available for the treatments studied, and to the best of our knowledge representing the first cost-effectiveness analysis of a register-enriched randomised controlled trial.
Finally, the patient survey will provide quality of life measures or utilities to enable cost-utility and cost-effectiveness analyses to be carried out.
