Exact(2)
According to the genome-wide binding behavior across different conditions, transcription factors could categorized into four major classes: conditional invariant, conditional enabled, conditional expanded, and conditional altered transcription factors [ 36].
Finally, posterior probability maps enabled conditional or Bayesian inferences about regionally specific effects, allowing us to ensure that a lack of significant statistical effect in a given contrast was not merely due to a failure to detect this effect using classical inferences [24].
Similar(58)
This general strategy for regulating protein stability should enable conditional perturbation of specific proteins with unprecedented control in a variety of experimental settings.
RNA silencing is a powerful research tool that enables conditional and titratable expression reduction of specific genes and thus aids functional analyses.
[ 363] and enable conditional genetic modifications for mechanistic and target validation studies [ 364].
One of our key goals in developing the AID system was to enable conditional protein depletion in the germ line.
Thus, crossing a Cre driver mouse with a mouse carrying a floxed gene enables conditional mutagenesis in an inducible way.
To address this, we have adapted the auxin-inducible degradation (AID) system discovered in plants to enable conditional protein depletion in C. elegans.
To determine the molecular function of the second step of hypusine modification in mammals, we generated a mouse strain enabling conditional knockout of Dohh (B6.Dohhtm1bal).
Summary: The auxin-inducible degradation (AID) system is adapted to C. elegans to enable conditional depletion of degron-tagged protein targets in as little as twenty minutes.
The 29-13 strain expresses the tetracycline repressor and the viral T7 RNA polymerase, which enables conditional expression of double stranded RNA leading to RNAi-mediated gene inhibition (Wirtz et al., 1999; Wang et al., 2000).
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