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Since many carcinogens require metabolic activation via phase I enzymes to enable to react with cellular macromolecules or metabolic detoxification via phase II enzymes to enable to eliminate from body, inter-individual differences in carcinogen metabolism may play a key role in environmental cancers [ 4, 6].
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The ultimate goal of diagnostics in CSF is to detect the earliest meaningful sign of neoplastic presence in the CSF to enable clinicians to react with the most relevant therapy.
Since many carcinogenic compounds require metabolic activation to enable them to react with cellular macromolecules, individual features of carcinogen metabolism may play an essential role in the development of environmental cancer.
These gallium oxide sites appear more active than the normal ones because of their location near the zeolite pore openings which enables them to react with both inward-and outward-diffusing molecules.
The chemical structure characteristic (triterpene quinine methide) of celastrol enables it to react with the nucleophilic thiol groups of cysteine residues in proteins and form covalent Michael adducts.
Radicals induced by postprandial hyperglycaemia or other reasons [ 4, 31], such as superoxide anion radical and hydroxyl radical, have the very high reactivity which enables them to react with a wide range of molecules, such as protein, lipids, and nucleotides leading to occurrence and development of a variety of diseases including T2DM [ 3, 32].
However, the Chl extract may also directly protect DNA from the electrophilic metabolites of the mutagen given that favonoids provide strong nucleophilic centers, which enables them to react with electrophilic mutagens and form adducts that may result in the prevention of genotoxic damage [ 54].
The azides enable the glycans to react with fluorophores, molecules that fluoresce when exposed to light of specific wavelengths.
The nickel doesn't react with the oils, instead it acts as a molecular machine, enabling the oils to react with the hydrogen.
The carboxyl (-COOH) groups of HRP was activated by EDC solution, enabling the HRP to react with (-NH2) generated on the surface of a nanopore chip.
In the case of persimmon pudding, excess baking soda enables the egg and flour proteins to react with the fruit sugars at temperatures no higher than the boiling point, and that reaction occurs throughout the batter rather than just on the surface.
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