The genetically engineered E. coli LZ41 and LZ54 strains contain drug-resistant topoisomerase gene alleles enabling to selectively inhibit either DNA gyrase or topoisomerase IV activity and respectively induce either relaxation or high negative supercoiling [ 30].
From these experiments we concluded that disruption of the pathways that enable UDCA to inhibit cell growth can also lead to resistance to the cytotoxic effects induced by other bile acids.
Piscidins are one of the most potent AMPs found in both freshwater and marine teleosts [ 11- 17] and their antimicrobial properties enable them to inhibit the growth of bacteria, fungi, viruses and parasites [ 14, 18- 21].
It is conceivable that non-microbial factors including menstruation, sexual intercourse as well as vaginal practices engaged in by women to manage their vaginal health and sexual life could possibly disturb the vaginal ecological conditions such as the low pH, which enable lactobacilli to inhibit overgrowth by other microorganisms in the vagina [ 23– 25].
For example, MSCs can promote breast cancer neoangiogenesis, possibly thorough the secretion of macrophage inflammatory protein 2 (MIP-2), VEGF, TGF- β, and IL-6 [ 187] and display potent immunomodulatory properties [ 188] that enable them to inhibit CTLs and NK cells by stimulating Tregs through the release of TGF- β1 [ 189].
Our method, which involves blocking the S1 region of the active site with malonate, enables one to inhibit fully the inactivating autolysis in human caspases and increases the yields of renatured active enzyme.
The capacity to bind to and transport Aβ enables albumin to inhibit Aβ polymerization and to increase Aβ clearance [12], [25] (Fig. 4).
They also contained a C-terminal extension with a SNSL amino acid motif enabling them to inhibit legumain C13 cysteine proteases [ 22].
Finally, RAMP-2 siRNA enabled us to inhibit the AM co-receptor because it inhibited AM-induced adhesion by 48%, 62%, and 72% (P < 0.0001) with 5, 10, and 20 n M RAMP-2 siRNA, respectively.
Their application in a specially designed blood filtration module enabled to almost totally inhibit blood cells interactions with membrane material, as well as to importantly reduce platelet activation in the permeate (2.5-fold reduction).
