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Small clinical trials are trials in which the number of patients does not enable the objective of the study to be appropriately met with the usual methodological rules.
Quantitative measures enable the objective comparison of research results and play a crucial role in their evaluation.
Molecular network reconstructions enable the objective, top-down assessment of regulatory challenges and functional capabilities associated with particular phenotypic states.
Such versatile EMT scoring may enable the objective and systematic investigation of EMT across many parameters of cancer progression, survival and throughout the clinical response to therapy.
The large cohort of patients, particularly for NEXT, will enable the objective evaluation of the safety and efficacy profiles of Nivestim™.
Within the context of the Rotterdam Scan Study, a standardized image analysis workflow is being developed, validated and applied to all imaging data, to enable the objective, accurate, and reproducible extraction of relevant parameters describing brain anatomy, possible brain pathologies, and structural and functional brain connectivity from multispectral MRI data.
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The key performance indicators enable the objectives to be correctly fulfilled.
First, the KEC-based method was standardized in a systematic fashion using ArcGIS, enabling the objective and quantitative acquisition of various attribute datasets.
Movement analysis by body-fixed inertial sensors containing accelerometers and gyroscopes enables the objective assessment of the translational and angular movements of body segments outside a gait laboratory [ 44, 45].
Flow cytometry has enabled the objective assessment of cellular morphology and activity, which can also be biochemically evaluated by measuring products of cellular metabolism, such as cyclic 3'5' guanosine monophosphate (cGMP).
Finally, the employment of these tools will enable the more objective verification of the success or failure of the therapeutic approach and will also implicate the patient himself/herself in the management of the condition.
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