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Of note, such population shift mechanisms enable the modulation of binding affinities in a versatile manner by the extent to which the higher affinity conformer is populated, as well as by the difference in binding affinities of the different conformers.
Consequently, the exercise-training programmes based on duty cycle alterations enable the modulation of metabolic stress within recognized exercise domains and the evaluation of this factor on vascular parameters.
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The usefulness of these negatively photochromic systems is only gradually coming to the fore with the advantages of low energy activation c.f. conventional Uv-activated switches, enabling the modulation of a plethora of useful optical and physical properties and the design of new materials with broad ranging applications.
The combination with inducible promoters permits temporal control of effector gene expression and enables the modulation of the response intensity by adjusting the duration of the heat-shock treatment.
Clinical Perspective on p 2384 A number of important LTCC subpopulations have been identified in ventricular myocytes that associate with unique macromolecular signaling complexes and scaffolding proteins, which enables the modulation of Ca2+ signaling.
Addressing these challenges will enable the rational modulation of both the thermodynamic and kinetic aspects of therapeutic delivery.
Expression of genes encoding such designed transcriptional regulators enable the selective modulation of endogenous gene expression.
We have demonstrated that compounds such as 4 (may61) may inhibit PAR1 in an allosteric fashion, which could enable the selective modulation of platelet activation pathways.
How the 2 regions functionally interact to enable the observed modulation of memory consolidation remains to be established because previously reported functional interactions between the hippocampus and the SN/VTA do not fully account for the behavioral effect while the putamen, a region without known anatomical connectivity to the hippocampus, does.
Chemical functionalization of molecules (biotin [15], phosphorylation [16], and charged dye [17]) at the entrance of the CNT core enables the modest modulation of ionic transportation.
This enabled the effective modulation of two central growth control pathways resulting in the phenotypic outcome of cell cycle reentry in postmitotic islet cells.
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